![]() ![]() P-value of 5% or less was considered statistically significant. The chi-square test or Fisher's exact test were applied for non-liner parameters. The two-sample t-test was applied for testing differences between the study groups for quantitative parameters. Subcortical FLAIR lesions were quantified according to the Fazekas score ( 4).įollow up data regarding future vascular events and mortality was accrued from outpatient visits to the neurology clinic as well as from medical records.ĭata analysis was performed with the statistical software SPSS version 24 (IBM USA). The MRI scans were studied for the number, size, and locations of hippocampal DWI lesions, presence of extra-hippocampal DWI, and presence and location of fluid attenuated inversion recovery (FLAIR) lesions. Primary clinical outcomes included functional outcomes, survival at 90 days, and the occurrence of recurrent stroke during follow up. Demographics and vascular risk factors were compared. Patients with hippocampal DWI restriction (DWI+) were compared to TGA-patients without DWI lesions (DWI-). All MRI evaluations were performed by an experienced stroke neurologist (NS) blinded to the clinical and outcome data including ischemic recurrence. To qualify as DWI restrictive lesion, a lesion had to hyper-intense on b1000 DWI and hypo-intense on the acquired diffusion coefficient (AC) maps. DWI MRI acquisitions were performed on 1.5T or 3T scanners in axial projections. Most of the patients were admitted to the stroke unit for initial evaluation and all include patients underwent evaluation by experienced stroke physicians.įor the purpose of the current study, we included patients who also had brain MRI scans during the acute admission. Per institutional protocol all patients with suspected TGA were admitted to the department of Neurology and underwent telemetry for at least 48 h. Patients diagnosed with TGA according to the Hodges and Warlow criteria ( 2), were included in this retrospective analysis. The research received approval of the ethics committee at Hadassah-Hebrew University Medical Center (0326–21-HMO). The research was performed in accordance with the Helsinki declaration and rules of Good Clinical Practice. Therefore, we aimed to determine the clinical and radiological characteristics of TGA-patients with possible acute micro-embolic stroke on diffusion-weighted imaging (DWI). It is important to determine whether TGA could be secondary to cerebral ischemia, because uncertainty about the etiology and prognosis of TGA could lead to potentially unnecessary evaluations on the one hand and under-evaluation of stroke risk may lead to high rates of stroke recurrence on the other ( 3). Transient global amnesia (TGA) is a clinical syndrome characterized by sudden onset of anterograde and retrograde memory loss that lasts up to 24 h and is accompanied by repetitive questioning without focal neurological symptoms or signs ( 1).ĭespite several proposed potential mechanisms, the precise pathogenesis of TGA often remains unclear ( 1– 3). The presence of AF in patients with TGA could suggest an increased risk of subsequent stroke. In contrast, none of the DWI- patients had recurrent events.Ĭonclusion: AF is common among DWI+ TGA-patients. None of the patients died, however, two DWI+ patients had subsequent stroke during a 2-year follow up and both had AF. 7%, p = 0.04) but the frequency of other risk factors did not differ. DWI+ patients more often had a history of atrial fibrillation (AF, 26 vs. Results: Out of 83 patients diagnosed with TGA, 56 (65%) underwent MRI during the acute hospitalization and 26 (46%) had new hippocampal DWI lesions. Demographics, risk factors, clinical data, radiological data, and mortality were analyzed. Methods: TGA-patients that had new DWI hippocampal lesions (DWI+) were compared to DWI negative TGA-patients (DWI–). ![]() We aimed to determine the clinical and radiological characteristics of TGA-patients with suspected acute micro-embolic stroke on diffusion-weighted imaging (DWI). 4Department of Neurology, Sourasky Medical Center, Tel Aviv, Israelīackground and Purpose: The etiology of transient global amnesia (TGA) remains unclear in a large subset of patients.3Department of Neurology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.2The Azrieli Faculty of Medicine, Bar Ilan University, Safed, Israel.1Department of Neurology, Ziv Medical Center, Safed, Israel.Naaem Simaan 1,2 Asaf Honig 3 Andrei Filioglo 3 Molad Jeremy 4 Ronen R. ![]()
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